Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in OdaphC41*/C41* mice
نویسندگان
چکیده
منابع مشابه
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis.
The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development. Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell l...
متن کاملHeterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks.
Beaks are innovative structures characterizing numerous tetrapod lineages, including birds, but little is known about how developmental processes influenced the macroevolution of these important structures. Here we provide evidence of ontogenetic vestigialization of alveoli in two lineages of theropod dinosaurs and show that these are transitional phenotypes in the evolution of beaks. One of th...
متن کاملCorrection for Wang et al., Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks.
EVOLUTION Correction for “Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks,” by Shuo Wang, Josef Stiegler, Ping Wu, Cheng-Ming Chuong, Dongyu Hu, Amy Balanoff, Yachun Zhou, and Xing Xu, which was first published September 25, 2017; 10.1073/ pnas.1708023114 (Proc Natl Acad Sci USA 114:10930–10935). The authors note that Fig. ...
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Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain. The timing and localization of PAG expression overlap with Fyn and Src, both of which we find associated to PAG. We demonstrate in newborn (P1) m...
متن کاملRho GTPases in ameloblast differentiation
During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial-mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied by dynamic cytoskeletal reorganization and...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-020-80912-y